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Showing 1–14 of 14 results
Advanced filters: Author: Adam D. Douglass Clear advanced filters

  • Detecting and responding to noxious stimuli is essential for survival. Wee et al. show that noxious stimuli elicit intense and widespread activity in zebrafish oxytocin neurons, which promote defensive behavior by activating hindbrain premotor neurons.

    • Caroline L. Wee
    • Maxim Nikitchenko
    • Adam D. Douglass
    Research
    Nature Neuroscience
    Volume: 22, P: 1477-1492

  • The microbial rhodopsin protein, Archaerhodopsin 3, can function as a rapid and highly sensitive genetically encoded voltage indicator in mammalian cells that is capable of detecting single action potentials with a signal-to-noise ratio greater than 10. A mutant lacking proton pumping displays greater sensitivity but a slowed response.

    • Joel M Kralj
    • Adam D Douglass
    • Adam E Cohen
    Research
    Nature Methods
    Volume: 9, P: 90-95

  • Genetically encoded voltage sensors are useful tools for the analysis of membrane potential and its influence on cell function. Here, the authors present a range of these sensors with varying colours for rapid and sensitive neuronal voltage imaging.

    • Peng Zou
    • Yongxin Zhao
    • Adam E. Cohen
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • This Review proposes an interdisciplinary framework for researching climate–society interactions that focuses on the mechanisms through which climate change has influenced societies, and the uncertainties of discerning this influence across different spatiotemporal scales.

    • Dagomar Degroot
    • Kevin Anchukaitis
    • Natale Zappia
    Reviews
    Nature
    Volume: 591, P: 539-550

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.

    • Hongxu Ding
    • Eugene F. Douglass Jr.
    • Andrea Califano
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The authors devised a method for detecting the bioluminescent Ca2+ sensor GFP-Aequorin in freely behaving zebrafish larvae. To demonstrate the efficacy of the technique, they targeted the sensor to a genetically specified population of hypothalamic neurons. The resulting neuroluminescence reveals patterns of neuronal activity that are associated with distinct swimming behaviors.

    • Eva A Naumann
    • Adam R Kampff
    • Florian Engert
    Research
    Nature Neuroscience
    Volume: 13, P: 513-520

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698