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Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

The epigenetic mechanisms underlying phenotypic diversity across different metastatic sites in castration-resistant prostate cancer (CRPC) remain to be characterised. Here, multi-omic profiling across metastatic lesions identifies regulatory networks driving tumour lineage programs and potential therapeutic targets.

Kei Mizuno
Sheng-Yu Ku
Himisha Beltran
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes

Enhancer of zeste homolog 2 (EZH2) has been implicated as a driver of disease progression and resistance to hormonal therapies. Here, the authors focus on EZH2 in two subtypes of advanced prostate cancer and report how it modulates the bivalent genes thereby leading to forward differentiation after being targeted in neuroendocrine prostate cancer.

Varadha Balaji Venkadakrishnan
Adam G. Presser
Himisha Beltran
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Improved reference genome of Aedes aegypti informs arbovirus vector control

An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

Benjamin J. Matthews
Olga Dudchenko
Leslie B. Vosshall
ResearchOpen Access14 Nov 2018
Nature

Volume: 563, P: 501-507
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al. show that BH3 mimetics, which inhibit pro-survival proteins BCL-2 or MCL-1, can effectively eliminate diseased cells.

Cameron S. Fraser
Johan K. E. Spetz
Kristopher A. Sarosiek
ResearchOpen Access02 Oct 2022
Nature Communications

Volume: 13, P: 1-19
High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment

John Sluimer
Willem M. R. van den Akker
Adam Meijer
ResearchOpen Access16 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes

Improved reference genome of Aedes aegypti informs arbovirus vector control

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment

AI is a viable alternative to high throughput screening: a 318-target study

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes

Improved reference genome of Aedes aegypti informs arbovirus vector control

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment

AI is a viable alternative to high throughput screening: a 318-target study

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Search

Quick links