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Nature Medicine (3)
Nature Methods (1)

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Showing 1–4 of 4 results

Advanced filters: Author: Adam J. Widman Clear advanced filters

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Alexandre Pellan Cheng
Adam J. Widman
Dan A. Landau
Research11 Apr 2025
Nature Methods

Volume: 22, P: 973-981
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables monitoring of minimal residual disease and immunotherapy response in settings of low tumor burden.

Adam J. Widman
Minita Shah
Dan A. Landau
Research14 Jun 2024
Nature Medicine

Volume: 30, P: 1655-1666
CD8⁺ T cells contribute to survival in patients with COVID-19 and hematologic cancer

A study of hospitalized patients infected with SARS-CoV-2 and who have liquid or solid cancer suggests that hematologic malignancy is an independent risk factor for mortality and that CD8⁺ T cells might limit infection in this setting irrespective of humoral immunity.

Erin M. Bange
Nicholas A. Han
Alexander C. Huang
Research20 May 2021
Nature Medicine

Volume: 27, P: 1280-1289
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

A new approach for whole-genome sequencing of plasma circulating tumor DNA allows for dynamic monitoring of disease burden and ultra-sensitive detection of minimal residual disease.

Asaf Zviran
Rafael C. Schulman
Dan A. Landau
Research01 Jun 2020
Nature Medicine

Volume: 26, P: 1114-1124