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Integrin α_v contributes to the regulation of vascular smooth muscle cell stiffness

Rümeyza Bascetin
Ekaterina Belozertseva
Patrick Lacolley
ResearchOpen Access07 Feb 2026
Scientific Reports

P: 1-11
Cancer risk and electromagnetic fields

Adam Lacy-Hulbert
Roger C. Wilkins
James C. Metcalfe
Research04 May 1995
Nature

Volume: 375, P: 23
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin α_V

Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4⁺ effector T cells use integrin α_V for interstitial migration on fibronectin in inflamed tissues.

Michael G Overstreet
Alison Gaylo
Deborah J Fowell
Research11 Aug 2013
Nature Immunology

Volume: 14, P: 949-958
αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production.

Mridu Acharya
Anna Sokolovska
Adam Lacy-Hulbert
ResearchOpen Access11 Mar 2016
Nature Communications

Volume: 7, P: 1-15
De-Mst-ifying microbicidal killing

Mitochondria can contribute to an increase in the amount of phagosomal reactive oxygen species and thereby promote the effective killing of bacteria. Study of mice deficient in Mst1 and Mst2 reveals a role for these kinases in recruiting mitochondria to phagosomes.

Lynda M Stuart
Adam Lacy-Hulbert
News & Views20 Oct 2015
Nature Immunology

Volume: 16, P: 1107-1108
Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian

Identifying core mechanisms of immune cells is critical for understanding the evolution of animal immune function. Here, Vandepas et al. report that ctenophore immune-like cells release extracellular DNA traps when exposed to microbes.

Lauren E. Vandepas
Caroline Stefani
Adam Lacy-Hulbert
ResearchOpen Access06 Apr 2024
Nature Communications

Volume: 15, P: 1-11
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

The molecular mechanisms behind recognition of altered self remain unclear. Moore and co-workers show that oxidized low-density lipoprotein (LDL) and β-amyloid trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6.

Cameron R Stewart
Lynda M Stuart
Kathryn J Moore
Research27 Dec 2009
Nature Immunology

Volume: 11, P: 155-161
Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.

Satish Khurana
Sarah Schouteden
Catherine M. Verfaillie
ResearchOpen Access01 Dec 2016
Nature Communications

Volume: 7, P: 1-14
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

The NLRP3 inflammasome is primarily known for producing inflammatory cytokines and inducing pyroptosis. Stuart and colleagues identify an additional role for NLRP3 in driving down the pH of phagosomes.

Anna Sokolovska
Christine E Becker
Lynda M Stuart
Research05 May 2013
Nature Immunology

Volume: 14, P: 543-553
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

Lipid-engorged macrophages accumulate in atherosclerotic plaques where chronic inflammation ensues. Moore and colleagues show that macrophage migration to chemokines and egress is arrested by netrin-1, which is secreted in the plaque lesions.

Janine M van Gils
Merran C Derby
Kathryn J Moore
Research08 Jan 2012
Nature Immunology

Volume: 13, P: 136-143
Targeting of α_v integrin identifies a core molecular pathway that regulates fibrosis in several organs

Dean Sheppard and his colleagues show that genetic or pharmacological inhibition of α_v integrin signaling ameliorates fibrosis in several solid organs.

Neil C Henderson
Thomas D Arnold
Dean Sheppard
Research10 Nov 2013
Nature Medicine

Volume: 19, P: 1617-1624

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