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The analysis of networks and network processes can require low-dimensional representations, possible for specific structures only. The authors propose a geometric formalism which allows to unfold the mechanisms of dynamical processes propagation in various networks, relevant for control and community detection.

The dynamics of a quantum system shows interesting features. Here the authors demonstrate critical scaling in the spin relaxation due to spin-exchange process in a system of impurity Cs atoms immersed in Rb atoms.

Endurance exercise is associated with an increased risk of atrial fibrillation. Here, the authors show the adipokine TNFα is a crucial mediator of exercise-induced atrial fibrillation and irreversible atrial remodelling characterized by fibrosis and inflammation.

Single-molecule force spectroscopy is used to correlate the single-molecule nanomechanical properties of a biomimetic polymer with the bulk mechanical performance of the material by means of the derivation of the potential energy landscape.

A hybrid protocell model is described in which a fatty acid membrane spontaneously assembles on the surface of coacervate microdroplets with molecularly crowded interiors. The membrane-enclosed protocells exhibit uptake and exclusion properties that differ from the uncoated droplets. The internal structure can be disassembled at high ionic strength without loss of membrane integrity. This model may help to reconcile alternative mechanisms of prebiotic compartmentalization.

Table-top laser-plasma ion accelerators have many potential applications, but achieving simultaneous narrow energy spread and high efficiency remains a challenge. Here, the authors produce ion beams with up to 18 MeV per nucleon whilst keeping the energy spread reduced through a self-organized process.

Catfish represent 6.3% of all vertebrate species, and occupy a phylogenetic position close to the common ancestor of bony fish. Liu et al. present a reference genome of the channel catfish, and reveal a genomic basis for the evolutionary loss of scales in these species.

Understanding how evolution of antimicrobial resistance increases resistance to other drugs is of key importance. Here, Lazar et al. build a map of cross-resistance interactions between antibiotics in Escherichia coliand show that chemical and genomic similarities are good predictors of bacterial cross-resistance.

Radiative bimolecular processes will dominate charge-carrier recombination in hybrid perovskite solar cells operating near the Shockley-Queisser limit. Here, the authors show that such processes are the inverse of absorption and increase as distribution functions sharpen towards lower temperatures.

Osteoporosis and bone fractures affect millions of patients worldwide and are often due to increased bone resorption. Here the authors identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ promoting the bone resorption function of osteoclasts.

Here the non-linear relationship is revealed between carbon emissions reductions and oil demand reductions, which depends on the magnitude of demand drop and the global oil market structure.

Oral verapamil lowers inflammatory markers and daily insulin needs in subjects with type 1 diabetes and helps preserve pancreatic beta cell function for at least two years. In this context, serum chromogranin A provides a promising therapy marker.

Merfin is a computational tool for variant filtering that improves accuracy in genotyping and genome assembly polishing.

Investigations in mice using parabiosis and cohousing experiments reveal that nonlymphoid organs serve as reservoirs of tissue-autonomous cellular immunity, leading to the decentralization of organism-level immune homeostasis.

Here, the authors simulate COVID-19 outbreaks on an empirical contact network derived from digital contact data collected on cruise ships. They model impacts of different control measures and find that combinations of measures, particularly vaccination and rapid antigen testing, are important for mitigating outbreaks.

The predominant threats to pollinators vary across locations, as do perceptions of the consequences of pollinator loss. Here, the authors use formal expert elicitation methods to identify how pollination conservation experts rank the various drivers of pollinator decline and the range of risks to humans if pollination activity is lost.

Historical accounts of the mortality outcomes of the Black Death plague pandemic are variable across Europe, with much higher death tolls suggested in some areas than others. Here the authors use a ‘big data palaeoecology’ approach to show that land use change following the pandemic was spatially variable across Europe, confirming heterogeneous responses with empirical data.

Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage sequencing and a Monte Carlo mathematical model.

High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination with bortezomib or venetoclax in preclinical models of multiple myeloma and acute myeloid leukemia.

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Ceramides in peripheral tissues contribute to obesity-related metabolic dysfunction. This study reveals that CerS6-derived ceramides induce hypothalamic lipotoxicity in mice via altered ER/mitochondrial homeostasis.

Surface heterogeneity is generally acknowledged as the major cause of liquid–solid friction, affecting whether droplets slide off the surface or stick to it. Now, a model surface of self-assembled monolayers has been used to investigate how molecular-scale surface heterogeneity affects water contact angle hysteresis and contact line friction. The high-coverage hydrophobic surface is slippery, as—counter-intuitively—is the low-coverage hydrophilic surface.

SlyB, a lipoprotein in the PhoPQ stress regulon in Gram-negative bacteria, forms stable stress-induced complexes with the outer membrane proteome.

The exploitation of ecosystems has long-lasting consequences for the future provision of natural resources and ecosystem services. Here the author showed that the transition to sustainable harvest after a period of over-harvesting leads to a decline in welfare, economic growth, and in the discount rate.

A field investigation at a former nuclear waste disposal site shows how environmental stress modulates subsurface microbial community assembly.

Using a battery of statistical tools, Alagöz et al. examine the genetic overlap between dyslexia and rhythm impairment and shed light on how the genome influences the neural bases of human language and musicality.

Transcription preinitiation complex assembly begins with the recognition of the gene promoter by the TATA-box Binding Protein-containing TFIID complex. Here the authors present a Cryo-EM structure of promoter-bound yeast TFIID complex, providing a detailed view of its subunit organization and promoter DNA contacts.

The production of ammonia via the Haber–Bosch process is carbon-intensive and centralized, but electrochemical methods such as lithium-mediated processes in organic electrolytes could enable decentralized production using renewable energy. Calcium is now shown to mediate nitrogen reduction for ammonia synthesis.

A phase 1 feasibility trial shows that bilateral deep brain stimulation within the central lateral thalamus can be safely applied and is associated with improved executive control.

Examination of archaeological pottery residues and modern genes suggest that environmental conditions, subsistence economics and pathogen exposure may explain selection for lactase persistence better than prehistoric consumption of milk.

Elastic anisotropy of liquid crystals elastomers is typically measured at low frequencies for the applications such as soft robotics, actuators, and origami. Here the authors study the elastic anisotropy of LCE using Brillouin light spectroscopy at gigahertz frequencies such as radio frequencies or 5 G cellular networks.

The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.

In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation.

Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution.

Small, portable artworks have been missing from the archaeological record of the earliest Homo sapiens of Southeast Asia–Australasia. New excavations in Sulawesi have uncovered stone engravings of the natural world dating back to 26–14 ka.

New reference genomes of the two extant monotreme lineages (platypus and echidna) reveal the ancestral and lineage-specific genomic changes that shape both monotreme and mammalian evolution.

ESCRT-III proteins assemble into ubiquitous membrane-remodeling polymers during many cellular processes. Here, the authors use cryo-ET, cryo-EM and mathematical modeling to reveal how the shape of the helical membrane tube arises from the assembly of two distinct bundles of helical filaments.

DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of polymerase delta on both strands during replication initiation and termination.

Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a potential therapeutic target.

In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.

An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

Aldosterone-producing zona glomerulosa cells in the adrenal gland arrange into rosette structures known to be important for morphogenesis. Here the authors show that the cells in the rosettes produce coordinated calcium activity bursts in response to angiotensin II that correlate with aldosterone production level.

Diorganozinc reagents (ZnR₂, e.g. R = Et, Ph, C₆F₅) are widely used as Lewis acid catalysts or Lewis base reagents, however, descriptors for predicting the influence of the R substituent are scarce. Here, by using liquid-phase X-ray spectroscopy, the authors have identified the geometric structures of diorganozincs in weakly coordinating solvents and then established Zn-specific descriptors to quantify the properties of their underlying Lewis acidity/basicity.

Coastal systems have enormous carbon-sequestering potential, but any positive climate effects can be countered by methane emissions. Here the authors use sea level rise manipulation mesocosms in tidal wetlands to show that shifts in plant community composition have the greatest effect on methane emissions.

Atomically thin sheets of graphite are metal-like conductors — until they react with hydrogen, when they become insulators. This curious effect could be an excellent model for studying metal–insulator transitions.

A subset of antigen-presenting cells of myeloid origin that require PRDM16 and RORγt regulates T cell function to enable immune tolerance of food and commensal gut microorganisms.

The global warming slowdown has been attributed to the negative phase of the Pacific Decadal Oscillation. Modelling work simulates this negative phase in response to anthropogenic aerosols, indicating that external forcings may influence natural cycles.

A multiomics approach is used to produce a spatiotemporal atlas of the human maternal–fetal interface in the first half of pregnancy, revealing relationships among gestational age, extravillous trophoblasts and spiral artery remodelling.

The authors investigate marine heatwaves on the ocean bottom in the shallow waters surrounding North America. Relative to their surface counterparts, bottom marine heatwaves are often more intense, more persistent, and can occur independently.