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Showing 1–3 of 3 results
Advanced filters: Author: Adam Vandergriff Clear advanced filters
  • Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.

    • Phuong-Uyen C. Dinh
    • Dipti Paudel
    • Ke Cheng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Stem cells exert their beneficial effects through secretion of regenerative factors. Here, the authors take the membranes and secreted factors from cardiac stem cells and generate a synthetic cell-mimicking microparticle, which, on injection in a mouse model of myocardial infarction, improves cardiac function.

    • Junnan Tang
    • Deliang Shen
    • Ke Cheng
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9
  • The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.

    • Junnan Tang
    • Teng Su
    • Ke Cheng
    Research
    Nature Biomedical Engineering
    Volume: 2, P: 17-26