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Natural killer cell memory in infection, inflammation and cancer

This Review focuses on our growing understanding of immunological memory behaviour in natural killer (NK) cells. The authors discuss the development and functions of memory NK cells and consider the potential of targeting these populations for vaccination or therapeutic purposes.

Adelheid Cerwenka
Lewis L. Lanier
Reviews25 Jan 2016
Nature Reviews Immunology

Volume: 16, P: 112-123
Natural killer cells, viruses and cancer

Adelheid Cerwenka
Lewis L. Lanier
Reviews01 Oct 2001
Nature Reviews Immunology

Volume: 1, P: 41-49
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

Loss of RNF20 is associated with aggressive cancer phenotypes. Here the authors show that Rnf20 haploinsufficiency leads to the formation of lung tumours due to defective DNA repair and HIF1α-mediated metabolic rewiring.

Hao Liu
Yongqin Tang
Gergana Dobreva
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-22
Checkpoint inhibition: NK cells enter the scene

Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody–mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.

Ana Stojanovic
Adelheid Cerwenka
News & Views18 Jun 2018
Nature Immunology

Volume: 19, P: 650-652
Type 1 T_reg cells promote the generation of CD8⁺ tissue-resident memory T cells

Tissue-resident memory T (T_RM) cells provide rapid front-line protection against infection. Veldhoen and colleagues demonstrate that the type 1 regulatory T cell subset supports generation of T_RM cells.

Cristina Ferreira
Leandro Barros
Marc Veldhoen
Research18 May 2020
Nature Immunology

Volume: 21, P: 766-776
TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

TREM-1 is a receptor that amplifies acute pro-inflammatory responses in infection. Here the authors show that TREM-1 plays an important role in atherosclerosis, a chronic and non-infectious disease, by critically skewing myelopoiesis towards preferential monocyte differentiation and by contributing to CD36-driven cellular lipid accumulation.

Daniel Zysset
Benjamin Weber
Christoph Mueller
ResearchOpen Access20 Oct 2016
Nature Communications

Volume: 7, P: 1-16
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.

Georg Gdynia
Sven W. Sauer
Wilfried Roth
ResearchOpen Access07 Mar 2016
Nature Communications

Volume: 7, P: 1-13
TREM-1 multimerization is essential for its activation on monocytes and neutrophils

Kevin Carrasco
Amir Boufenzer
Marc Derive
Research22 Mar 2018
Cellular & Molecular Immunology

Volume: 16, P: 460-472
MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells

Christian Breunig
Jens Pahl
Stefan Wiemann
ResearchOpen Access03 Aug 2017
Cell Death & Disease

Volume: 8, P: e2973

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