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Showing 1–3 of 3 results
Advanced filters: Author: Adeline Mayeux Clear advanced filters
  • Cells normally grow to a certain size before they enter mitosis and divide, and entry into mitosis is known to be dependent on the activity of Cdk1; however, how this is sensed remains unknown. Here, and in an accompanying paper, it is shown that an intracellular polar gradient of dual-specificity the tyrosine-phosphorylation regulated kinase (DYRK) Pom1 relays size information to the Cdk1 inhibitor Wee1.

    • James B. Moseley
    • Adeline Mayeux
    • Paul Nurse
    Research
    Nature
    Volume: 459, P: 857-860
  • EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.

    • Julie Salomon
    • Cécile Gaston
    • Delphine Delacour
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18