Cells normally grow to a certain size before they enter mitosis and divide, and entry into mitosis is known to be dependent on the activity of Cdk1; however, how this is sensed remains unknown. Here, and in an accompanying paper, it is shown that an intracellular polar gradient of dual-specificity the tyrosine-phosphorylation regulated kinase (DYRK) Pom1 relays size information to the Cdk1 inhibitor Wee1.
- James B. Moseley
- Adeline Mayeux
- Paul Nurse