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Showing 1–6 of 6 results
Advanced filters: Author: Adewola Osunsade Clear advanced filters

  • Using single-molecule imaging and manipulation, the authors show linker histone H1 preferentially forms phase-separated droplets with single-stranded nucleic acids over double-stranded DNA and nucleosomes, suggesting a noncanonical nuclear function.

    • Rachel Leicher
    • Adewola Osunsade
    • Shixin Liu
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 463-471

  • Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but this stress is dramatically attenuated by nucleosomes assembled on the DNA.

    • Tuan Nguyen
    • Sai Li
    • Shixin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 as a deglycase.

    • Qingfei Zheng
    • Nathaniel D. Omans
    • Yael David
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Protein arginine deiminase 4 (PAD4) facilitates the posttranslational citrullination of histones H3 and H4. Here, the authors provide evidence that PAD4 antagonizes histone methylglyoxal-glycation by rewriting the glycated arginine into citrulline and protecting the reactive sites from further glycation.

    • Qingfei Zheng
    • Adewola Osunsade
    • Yael David
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Mutations in histone H1 induce the remodelling of chromatin architecture to a more relaxed state, which leads to malignant transformation through changes in histone modifications and the expression of stem cell genes.

    • Nevin Yusufova
    • Andreas Kloetgen
    • Ari M. Melnick
    Research
    Nature
    Volume: 589, P: 299-305

  • Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and  histone methylation.

    • Michael A. Willcockson
    • Sean E. Healton
    • Arthur I. Skoultchi
    Research
    Nature
    Volume: 589, P: 293-298