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Showing 1–3 of 3 results
Advanced filters: Author: Adeyinka Ashaye Clear advanced filters

  • Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

    • Puya Gharahkhani
    • Eric Jorgenson
    • Janey L. Wiggs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

    • Tin Aung
    • Mineo Ozaki
    • Chiea Chuen Khor
    Research
    Nature Genetics
    Volume: 49, P: 993-1004

  • The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.

    • Clement A. Adebamowo
    • Adebowale Adeyemo
    • Sally N. Adebamowo
    Comments & Opinion
    Nature Genetics
    Volume: 54, P: 527-530