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Showing 1–6 of 6 results
Advanced filters: Author: Adi Ezra Clear advanced filters

  • Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenotype can be reversed with administration of a senolytic drug.

    • Yossi Ovadya
    • Tomer Landsberger
    • Valery Krizhanovsky
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Corticotrophin releasing factor (CRF) and its receptors are involved in the neuroendocrine and behavioral responses to stress. Here, Elliot and colleagues describe alterations in DNA methylation of the Crf gene that regulate its expression and show that these alterations correlate with resilience to social stress.

    • Evan Elliott
    • Gili Ezra-Nevo
    • Alon Chen
    Research
    Nature Neuroscience
    Volume: 13, P: 1351-1353

  • Andelman-Gur et al. use a nasal airflow monitoring device to detect alterations of respiratory dynamics in patients with Parkinson’s Disease. They reveal longer, but less variable, inhalations and show that changes in airflow dynamics are correlated with disease severity, plus 30 min of data is adequate to discriminate patients from controls.

    • Michal Andelman-Gur
    • Kobi Snitz
    • Noam Sobel
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-9

  • Despite data supporting the rapid adoption of telehealth in the delivery of clinical care in North America, the implementation of telehealth visits in clinical research studies has faced critical barriers. These challenges include: (1) variations in state licensure requirements for telehealth; (2) disparities in access to telehealth among disadvantaged populations; (3) lack of consistency among individual Investigational Review Boards (IRBs). Each barrier prevents the systematic conversion of research protocols to include telehealth visits. The Parkinson’s Foundation and members of the Parkinson Study Group submit this Comment to highlight current challenges to implementing telehealth visits for clinical research studies. Our objective is to provide a consensus statement emphasizing the urgent need for regulators to standardize adoption of telehealth practices and to propose recommendations to reduce the burden for implementation in existing research study protocols.

    • Anna Naito
    • Anne-Marie Wills
    • James C. Beck
    Comments & OpinionOpen Access
    npj Parkinson's Disease
    Volume: 7, P: 1-4