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Showing 1–9 of 9 results
Advanced filters: Author: Adi Millman Clear advanced filters

  • A study shows that many phages are capable of evading antiphage defence systems of bacteria by reconstituting NAD+ from its degradation products in infected cells.

    • Ilya Osterman
    • Hadar Samra
    • Rotem Sorek
    Research
    Nature
    Volume: 634, P: 1160-1167

  • Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacterial gasdermins that promote cell death.

    • Tanita Wein
    • Adi Millman
    • Rotem Sorek
    Research
    Nature
    Volume: 639, P: 727-734

  • The mechanism of Thoeris—a bacterial anti-phage defence system—is described in detail, revealing that bacterial TIR-domain proteins recognize infection and produce signalling molecules to execute cell death, akin to the roles of these proteins in plants.

    • Gal Ofir
    • Ehud Herbst
    • Rotem Sorek
    Research
    Nature
    Volume: 600, P: 116-120

  • Structures of prokaryotic homologues of STING permit the reconstruction of the evolutionary trajectory of its incorporation into metazoan innate immunity, and reveal a role for the conserved cGAS–STING pathway in prokaryotic defence against bacteriophages.

    • Benjamin R. Morehouse
    • Apurva A. Govande
    • Philip J. Kranzusch
    Research
    Nature
    Volume: 586, P: 429-433