Oligodendrocytes produce myelin in the central nervous system and can regenerate in adults. Brunet and colleagues show that inactivation of SIRT1 deacetylase increases the proliferation of oligodendrocyte progenitors partly by shifting other neural stem cells to this fate. Using genome-wide approaches, they delineate PDGFRα as a critical target of SIRT1 in its negative effects on oligodendrocyte lineage.
- Victoria A. Rafalski
- Peggy P. Ho
- Anne Brunet
