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Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial

The final analysis from the phase 3 IMpassion031 trial shows that adding atezolizumab to chemotherapy for stage II/III triple-negative breast cancer is associated with favorable long-term outcomes, with circulating tumor DNA clearance correlating with therapy response.

Elizabeth A. Mittendorf
Zoe June Assaf
Carlos H. Barrios
ResearchOpen Access04 Jun 2025
Nature Medicine

Volume: 31, P: 2397-2404
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

Epigenetic alterations alter chromatin structure and gene expression and are known contributors to cancer development. Here, Muratani et al.profile multiple epigenetic chromatin marks in primary gastric cancers and identify hundreds of altered promoters and enhancers that drive the gene expression program in these malignancies.

Masafumi Muratani
Niantao Deng
Patrick Tan
Research10 Jul 2014
Nature Communications

Volume: 5, P: 1-14
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic elements of hTERT.

TingDong Yan
Wen Fong Ooi
Shang Li
ResearchOpen Access08 Jan 2018
Nature Communications

Volume: 9, P: 1-15
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.

Wen Fong Ooi
Manjie Xing
Patrick Tan
ResearchOpen Access28 Sept 2016
Nature Communications

Volume: 7, P: 1-17
Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer

Sarina Cameron
Genevieve Deblois
Mathieu Lupien
ResearchOpen Access05 Apr 2023
Oncogene

Volume: 42, P: 1693-1703

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Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial

Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer

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