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Nature Communications (2)
Molecular Psychiatry (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Aditi Valada Clear advanced filters

Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia

HIV infection and substance use disorders converge in human midbrain. Here, authors show transcriptional impacts using single-nucleus RNA sequencing, linking dopaminergic vulnerability and microglial dysregulation, and in viremia, GABAergic deficits.

Alyssa M. Wilson
Michelle M. Jacobs
Schahram Akbarian
ResearchOpen Access14 Oct 2025
Nature Communications

Volume: 16, P: 1-23
Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

The cellular signatures of the opioid exposed human midbrain remain unexplored. Here, authors show by single nuclei transcriptomics activation of the glial immune response and dysregulation of synaptic signaling in opioid exposed individuals

Julong Wei
Tova Y. Lambert
Schahram Akbarian
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk

Samuel K. Powell
Callan O’Shea
Kristen J. Brennand
Research07 Sept 2021
Molecular Psychiatry

Volume: 28, P: 1970-1982