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Showing 1–6 of 6 results

Advanced filters: Author: Adrian Gottschlich Clear advanced filters

Programmable multispecific DNA-origami-based T-cell engagers

A synthetic nanocarrier based on DNA origami chassis offers control over valency, orientation and spatial arrangement of antibodies for simultaneously engaging immune signalling pathways, checkpoint inhibition and targeted co-stimulation in anticancer immunotherapy in vivo.

Klaus F. Wagenbauer
Nhi Pham
Hendrik Dietz
ResearchOpen Access17 Aug 2023
Nature Nanotechnology

Volume: 18, P: 1319-1326
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

A single-cell screening approach identifies targets for CAR-T cells in acute myeloid leukemia.

Adrian Gottschlich
Moritz Thomas
Sebastian Kobold
Research13 Mar 2023
Nature Biotechnology

Volume: 41, P: 1618-1632
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Multiomic factor analysis of blood multiomic data, including single-cell transcriptomics, for individuals with either acute or chronic coronary syndrome identifies immune cell signatures that correlate with treatment outcomes.

Kami Pekayvaz
Corinna Losert
Konstantin Stark
ResearchOpen Access21 May 2024
Nature Medicine

Volume: 30, P: 1696-1710
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Stefanie Lesch
Viktoria Blumenberg
Sebastian Kobold
Research03 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 1246-1260
Impact of the selective A2_AR and A2_BR dual antagonist AB928/etrumadenant on CAR T cell function

Matthias Seifert
Mohamed-Reda Benmebarek
Sebastian Kobold
ResearchOpen Access20 Oct 2022
British Journal of Cancer

Volume: 127, P: 2175-2185
A modular and controllable T cell therapy platform for acute myeloid leukemia

Mohamed-Reda Benmebarek
Bruno L. Cadilha
Sebastian Kobold
ResearchOpen Access07 Jan 2021
Leukemia

Volume: 35, P: 2243-2257