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Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids

Exosomal signaling from type 2 diabetes alters tumor–immune crosstalk, driving immunosuppression and tumor aggressiveness in breast cancer organoids through expansion of dysfunctional T cells and activation of invasive programs.

Christina S. Ennis
Michael Seen
Gerald V. Denis
ResearchOpen Access26 Aug 2025
Communications Biology

Volume: 8, P: 1-16

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Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids

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