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Showing 101–150 of 1584 results
Advanced filters: Author: Adrian J. Green Clear advanced filters
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Bio-inspired Ni-based molecular catalysts are efficient for H2 oxidation, but are suffering from the poor stability in the presence of O2. Here, the authors develop a strategy to boost greatly their stability by dispersing them in a hydrophobic and redox-silent polymer matrix.

    • Alaa A. Oughli
    • Adrian Ruff
    • Olaf Rüdiger
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-6
  • Nonselective engagement of GPCR signaling pathways by GPCR-targeting drugs can reduce treatment efficacy and cause side effects. The authors show that signaling selectivity in CB2R can be tuned by reshaping allosteric networks, offering insights for more precise therapies.

    • Adrian Morales-Pastor
    • Tamara Miljuš
    • Jana Selent
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • How the bones of the skull vault expand to cover the brain is poorly understood. Here, the authors demonstrate that such bones grow through a mechanical feedback mechanism that propagates a wave of differentiation and emergent cell motion.

    • Yiteng Dang
    • Johanna Lattner
    • Jacqueline M. Tabler
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The authors present a characterization of complex X-linked lncRNA loci with sex- and allele-specific epigenetic signatures that serve as a platform for the largest chromatin structures in mammals, thereby elucidating diverse phenotypes and combinatorial effects on autosomes.

    • Tim P. Hasenbein
    • Sarah Hoelzl
    • Daniel Andergassen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • Integrating an organic photodiode with a tandem OLED enables positive photonic feedback that results in bistable behaviour. Devices show giant hysteresis in their current–voltage–luminance characteristic and upconversion of near-infrared to visible light with 100-fold photon-to-photon gain.

    • Raju Lampande
    • Jon-Paul S. DesOrmeaux
    • Noel C. Giebink
    Research
    Nature Photonics
    Volume: 18, P: 1299-1304
  • Metaplastic breast cancer is a highly chemoresistant breast cancer subtype with limited therapeutic options. Here, the authors report that the NOS inhibitor, L-NMMA, sensitises metaplastic breast cancer to a selective PI3K inhibitor, alpelisib, and taxane chemotherapy via repression of c-JUN mediated epithelial-to-mesenchymal transition.

    • Tejaswini Reddy
    • Akshjot Puri
    • Jenny Chang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

    • Kevin C. Gonzalez
    • Adrian Negrean
    • Attila Losonczy
    Research
    Nature
    Volume: 637, P: 1152-1160
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • The synaptic vesicle protein 2 family are essential membrane proteins found in the brain that bind synaptotagmin and are targeted by anti-seizure medications. Structures reveal common features found in transport proteins, and the basis of ligand binding and selectivity.

    • Anshumali Mittal
    • Matthew F. Martin
    • Jonathan A. Coleman
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1964-1974
  • Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

    • Damaris Kinyoki
    • Aaron E. Osgood-Zimmerman
    • Simon I. Hay
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 1761-1782
  • Magnetic field has been observed to promote oxygen evolution at some circumstance, however the reason for the enhancement remains unclear. Here, the authors show that enhancement is due to the disappearance of magnetic domain walls.

    • Xiao Ren
    • Tianze Wu
    • Zhichuan J. Xu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms persist, although populations of several organisms have begun to re-establish despite persistent physical changes at the seafloor.

    • Daniel O. B. Jones
    • Maria Belen Arias
    • Adrian G. Glover
    ResearchOpen Access
    Nature
    Volume: 642, P: 112-118
  • The detection of conserved motifs by pattern recognition receptors is a crucial component of the innate detection of pathogens and danger signals via conserved pattern recognition receptors. Here the authors define a pathway that transfers partially digested material from the phagolysosomal pathway of macrophages to release at the plasma membrane which is associated with enhanced inflammatory potential, by a process they introduce as eructophagy.

    • Catherine J. Greene
    • Jenny A. Nguyen
    • Robin M. Yates
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • Comprehensive solution and solid-state characterization of an adduct between a Lewis acidic perfluoroaryl borane and an electron-rich silane is demonstrated. This has long been proposed as an intermediate in the ‘frustrated’ Lewis-pair hydrosilylation of C=C, C=O and C=N double bonds, but its existence has, so far, only been inferred from indirect experimental evidence.

    • Adrian Y. Houghton
    • Juha Hurmalainen
    • Heikki M. Tuononen
    Research
    Nature Chemistry
    Volume: 6, P: 983-988
  • In this work, the authors develop mirror-image monobodies (Mb) made of D-amino acids against the BCR::ABL1 SH2 domain with high binding affinities. The heterochiral Mb-SH2 structures reveal an unusual binding mode. The D-Mbs are protease-resistant, inhibit BCR::ABL1 kinase activity and bind BCR::ABL1 in cell lysates.

    • Nina Schmidt
    • Amit Kumar
    • Oliver Hantschel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • Signs of instability in the Antarctic Larsen C ice shelf have raised concerns that it might soon collapse like its northern neighbour Larsen B. Kulessa et al.combine an ice-shelf model with satellite and geophysical data to show that despite dynamic similarities, Larsen C is presently stabilized by marine ice.

    • Bernd Kulessa
    • Daniela Jansen
    • Peter R. Sammonds
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-7
  • Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

    • Isidro Cortés-Ciriano
    • Jake June-Koo Lee
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 331-341
  • Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.

    • Mehrnoosh Jafari
    • Adrian-Minh Schumacher
    • Martin Kerschensteiner
    Research
    Nature Neuroscience
    Volume: 24, P: 355-367
  • The molecular-level mechanism by which manganese enhances cobalt catalysts for Fischer−Tropsch synthesis (FTS) of long-chain hydrocarbons from syngas is not well understood. Here, the authors demonstrate that manganese promotes long-chain hydrocarbon production in Co-based FTS catalysts by binding H at basic O sites on MnO, reducing chain termination on Co and thus promoting C5+ products.

    • Hao Chen
    • Zan Lian
    • Miquel Salmeron
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Antibody immunoprophylaxis for HIV-1 will require effective concentration of biologics at mucosal sites of exposure for effectivity. Here the authors show that infused Fc-modified VRC01LS antibody has increased levels in blood, in the female genital tract and male rectal tissue, compared to native antibody VRC01. VRC01LS is detectable for more than year at the sites of sexual HIV transmission.

    • Maria P. Lemos
    • Rena D. Astronomo
    • M. Juliana McElrath
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • X-ray crystallography and cryo-electron microscopy analyses of Lettuce—a DNA mimic of GFP—bound to various fluorophores reveal previously unknown structures of DNA that rival analogous RNAs in complexity.

    • Luiz F. M. Passalacqua
    • Michael T. Banco
    • Adrian R. Ferré-D’Amaré
    Research
    Nature
    Volume: 618, P: 1078-1084
  • The tumor suppressor ARF is retained by nucleophosmin (NPM) in nucleoli, but shifted out upon DNA damage. In this study, the authors show that cytochrome c triggers a conformational change on NPM, driving ARF release and controlling protein trafficking.

    • Katiuska González-Arzola
    • Antonio Díaz-Quintana
    • Irene Díaz-Moreno
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1024-1036
  • Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de novo T and NK cell production for years, independently from HSCs.

    • Natalia Izotova
    • Christine Rivat
    • Luca Biasco
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710
  • The circadian rhythm generates out-of-equilibrium metabolite oscillations controlled by feedback loops under light/dark cycles. Now, it has been shown that these life-like properties can emerge from a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes capable of light-gated chemical communication, controllable feedback and coupling to macroscopic oscillations.

    • Omar Rifaie-Graham
    • Jonathan Yeow
    • Molly M. Stevens
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 110-118
  • Two small-molecule drugs, risdiplam and branaplam, have been developed for treating spinal muscular atrophy. Here the authors develop quantitative modeling methods for the sequence-specific and concentration-dependent effects of these and other splice-modifying drugs.

    • Yuma Ishigami
    • Mandy S. Wong
    • Justin B. Kinney
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Terahertz-frequency vibrational modes are thought to play a key role for DNA biological functions, yet observation of these fluctuations in solution has proven difficult so far. Here, the authors use femtosecond optical Kerr-effect spectroscopy to demonstrate their existence in physiologically relevant conditions.

    • Mario González-Jiménez
    • Gopakumar Ramakrishnan
    • Klaas Wynne
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-6
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.

    • Robert J. Trachman III
    • Alexis Autour
    • Adrian R. Ferré-D’Amaré
    Research
    Nature Chemical Biology
    Volume: 15, P: 472-479
  • Superconductivity often emerges at the vicinity of charge and bond-ordered states. Here, by studying ruthenates, the authors demonstrate that it can also be mediated by an electron-phonon coupling related to the proximity of orbital and bond-ordered phases.

    • Álvaro Adrián Carrasco Álvarez
    • Sébastien Petit
    • Julien Varignon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels increased survival of Drosophila models of ALS/FTD and patient neurons, suggesting that interventions that increase neuronal PUFA levels in patients with ALS/FTD may also be beneficial.

    • Ashling Giblin
    • Alexander J. Cammack
    • Adrian M. Isaacs
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 737-747