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Showing 1–2 of 2 results
Advanced filters: Author: Adriana E. Tron Clear advanced filters
  • MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted therapies overcomes this resistance.

    • Joan Montero
    • Cécile Gstalder
    • Rizwan Haq
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination with bortezomib or venetoclax in preclinical models of multiple myeloma and acute myeloid leukemia.

    • Adriana E. Tron
    • Matthew A. Belmonte
    • Alexander W. Hird
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14