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Showing 1–6 of 6 results
Advanced filters: Author: Adriana Gambardella Clear advanced filters

  • Meng et al. report that lymphoid fate is programmed epigenetically rather than transcriptionally in haematopoietic stem cells and shed light on how epigenetic programming generates platelet differentiation pathways with distinct kinetics.

    • Yiran Meng
    • Joana Carrelha
    • Claus Nerlov
    Research
    Nature Cell Biology
    Volume: 25, P: 812-822

  • With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

    • Amit Grover
    • Alejandra Sanjuan-Pla
    • Claus Nerlov
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

    • Joana Carrelha
    • Yiran Meng
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 554, P: 106-111

  • Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

    • Philipp S. Hoppe
    • Michael Schwarzfischer
    • Timm Schroeder
    Research
    Nature
    Volume: 535, P: 299-302

  • The identification of a functionally distinct subset of haematopoietic stem cells (HSCs) that is primed for platelet-specific gene expression is described; the cells frequently have long-term myeloid lineage bias, can self-renew and give rise to lymphoid-biased HSCs, and may enable the design of therapies for enhancing platelet reconstitution.

    • Alejandra Sanjuan-Pla
    • Iain C. Macaulay
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 502, P: 232-236