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Showing 1–5 of 5 results

Advanced filters: Author: Adrien Leger Clear advanced filters

Natural genetic variation quantitatively regulates heart rate and dimension

Using inbred medaka strains, the authors mapped 59 genetic loci linked to heart rate. Gene editing validated conserved genes affecting heart rate and morphology, highlighting the power of isogenic strains in uncovering mechanisms of cardiac traits and disease.

Jakob Gierten
Bettina Welz
Joachim Wittbrodt
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-12
RNA modifications detection by comparative Nanopore direct RNA sequencing

Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.

Adrien Leger
Paulo P. Amaral
Tony Kouzarides
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-17
NGS library preparation may generate artifactual integration sites of AAV vectors

Benjamin Cogné
Richard Snyder
Adrien Leger
Correspondence05 Jun 2014
Nature Medicine

Volume: 20, P: 577-578
The Interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post-transcription

Camille Bouillier
Gina Cosentino
Marie-Anne Rameix-Welti
ResearchOpen Access24 Oct 2019
Scientific Reports

Volume: 9, P: 1-13
High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice

Sébastien Rivière
Vanessa Soubeyre
Xavier Grosmaitre
ResearchOpen Access23 Sept 2016
Scientific Reports

Volume: 6, P: 1-13