Nature Search

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic epiblast. They establish naïve embryonic stem cells based on these insights.

Claire S. Simon
Afshan McCarthy
Kathy K. Niakan
ResearchOpen Access28 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Erratum: Genome editing reveals a role for OCT4 in human embryogenesis

Norah M. E. Fogarty
Afshan McCarthy
Kathy K. Niakan
Amendments and Corrections04 Oct 2017
Nature

Volume: 551, P: 256
TRF2-independent chromosome end protection during pluripotency

Experiments in mouse pluripotent embryonic and epiblast stem cells show that TRF2 is dispensable for telomere protection specifically specifically in the pluripotent cells that form during early embryonic development, when cells form T-loops independently of this protein.

Phil Ruis
David Van Ly
Simon J. Boulton
Research25 Nov 2020
Nature

Volume: 589, P: 103-109
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1^−/− and Msh5^−/− oocytes.

Elias ElInati
Agata P. Zielinska
James M. A. Turner
ResearchOpen Access25 May 2020
Nature Communications

Volume: 11, P: 1-10
Initiation of a conserved trophectoderm program in human, cow and mouse embryos

Comparative analysis of human, cow and mouse embryos shows that a mechanism involving atypical protein kinase C initiates the trophectoderm program during the morula stage in these three species.

Claudia Gerri
Afshan McCarthy
Kathy K. Niakan
Research23 Sept 2020
Nature

Volume: 587, P: 443-447
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sustain hESCs in the absence of FGF.

Sissy E. Wamaitha
Katarzyna J. Grybel
Kathy K. Niakan
ResearchOpen Access07 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Genome editing reveals a role for OCT4 in human embryogenesis

Genome editing in human zygotes shows that OCT4 is required for normal development at an earlier stage in humans than in mice.

Norah M. E. Fogarty
Afshan McCarthy
Kathy K. Niakan
Research20 Sept 2017
Nature

Volume: 550, P: 67-73
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

Bakal, Wong and colleagues performed an RNAi screen in Drosophila cells, as well as imaging and systems-level analyses, to identify genes regulating morphological complexity in heterogeneous cell populations. They report that rather than generating novel shapes, most genes control a switch-like transition between distinct morphologies. The authors also extend their findings to mouse and human melanoma cells.

Zheng Yin
Amine Sadok
Chris Bakal
Research09 Jun 2013
Nature Cell Biology

Volume: 15, P: 860-871

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