A quantitative genetic interaction map, or E-MAP, of ∼400 genes involved in plasma membrane biology, in combination with triplet genetic motif analysis, has led to the identification of a new component of the eisosome, Eis1, links the poorly characterized EMP70 gene to endocytic and eisosome functions, and uncovers a link between Rom2—a GDP/GTP exchange factor for Rho1 and Rho2—and the regulation of sphingolipid metabolism.
- Pablo S Aguilar
- Florian Fröhlich
- Tobias C Walther
