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Showing 1–5 of 5 results
Advanced filters: Author: Aishe Kurti Clear advanced filters

  • Liu and colleagues find differential effects of microglial apoE isoforms on brain function and microglial responses. ApoE3 enhances microglial responses, promoting brain function and reducing amyloid deposition and associated neurotoxicity, while the Alzheimer’s disease-associated apoE4 results in lipid droplet accumulation and impaired microglial responses, which are critical for limiting the development of amyloid pathology.

    • Chia-Chen Liu
    • Na Wang
    • Guojun Bu
    Research
    Nature Immunology
    Volume: 24, P: 1854-1866

  • The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy.

    • Na Zhao
    • Chia-Chen Liu
    • Guojun Bu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Zhang et al. show that the poly(GA) proteins produced in patients with C9ORF72 repeat expansions cause neurodegeneration and behavioral abnormalities when expressed in mice. The emergence of these phenotypes requires poly(GA) aggregation, and poly(GA) inclusions sequester HR23 proteins involved in proteasomal degradation, as well as proteins involved in nucleocytoplasmic transport.

    • Yong-Jie Zhang
    • Tania F Gendron
    • Leonard Petrucelli
    Research
    Nature Neuroscience
    Volume: 19, P: 668-677