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Showing 1–5 of 5 results
Advanced filters: Author: Akos A. Gerencser Clear advanced filters

  • The phenotype and function of immune cells could change during spaceflight. Here the authors use simulated microgravity, coupled to validation with spaceflight data, to assess whether there are distinct gene expression changes in resting and TLR 7/8 stimulated PBMCs and found conserved changes in IFN signalling, the cytoskeleton, IL-6 and sirtuin signalling.

    • Fei Wu
    • Huixun Du
    • Daniel A. Winer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by maintaining retromer-mediated protein and lipid trafficking.

    • Kenneth A. Wilson
    • Sudipta Bar
    • Pankaj Kapahi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Drosophila intestinal stem cells (ISCs) respond to changes in diet, particularly L-glutamate levels, by modulating Ca2+ signalling to adapt their proliferation rate; furthermore, Ca2+ is shown to be central to the response of ISCs to a wide range of dietary and stress stimuli.

    • Hansong Deng
    • Akos A. Gerencser
    • Heinrich Jasper
    Research
    Nature
    Volume: 528, P: 212-217

  • SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.

    • Aditi U. Gurkar
    • Akos A. Gerencser
    • João F. Passos
    Reviews
    Nature Aging
    Volume: 3, P: 776-790