Cyclodipeptide synthases use amino acid–loaded tRNAs as substrates to form cyclic peptide dimers. Biochemical and bioinformatic analyses now show that these enzymes are distributed into two phylogenetically distinct major subfamilies and use a broad range of substrates that can be predicted with newly defined sequence motifs.
- Isabelle B Jacques
- Mireille Moutiez
- Pascal Belin
