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Showing 1–16 of 16 results
Advanced filters: Author: Alan D Attie Clear advanced filters

  • Linke et al. use unbiased and quantitative techniques to directly link both known and unknown liver and plasma lipid moieties to specific genomic loci, as compiled in a public web resource, LipidGenie. LipidGenie aided in the identification of a new group of sex-specific phosphatidylcholines.

    • Vanessa Linke
    • Katherine A. Overmyer
    • Joshua J. Coon
    Research
    Nature Metabolism
    Volume: 2, P: 1149-1162

  • Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impacts of genetic variation on protein expression and lipid metabolism.

    • Qing Yu
    • Xinyue Liu
    • Steven P. Gygi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Distal gene regulation is increasingly recognised as a major contributor to complex trait variability. Here, the authors show that a heritable, biologically interpretable transcriptome signature driven by distal regulation predicts metabolic traits across mice and humans.

    • Anna L. Tyler
    • J. Matthew Mahoney
    • Gregory W. Carter
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • The impact of lowering lipids alone on the pathologic complications of Type 2 diabetes is unknown. Treatment with a novel antisense oligonucleotide directed against ApoC-III lowered triglycerides significantly in the leptin deficient BTBR ob/ob murine model of type 2 diabetes, but did not ameliorate hyperglycemia or improve the nephropathy.

    • Alan D. Attie
    • Kathryn M. Schueler
    • Charles E. Alpers
    Research
    Laboratory Investigation
    Volume: 101, P: 935-941

  • The mitochondrial phosphatase PPTC7 has previously been linked to the maintenance of mitochondrial content, but the mechanisms underlying this phenotype remain unclear. Here, the authors demonstrate that loss of Pptc7 results in metabolic defects and further suggest that PPTC7 is a regulator of receptor-mediated mitophagy.

    • Natalie M. Niemi
    • Lia R. Serrano
    • David J. Pagliarini
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protein import with the translocase subunit Timm50.

    • Natalie M. Niemi
    • Gary M. Wilson
    • David J. Pagliarini
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Lipoprotein lipase, the enzyme that hydrolyzes fatty acids from triglycerides carried by circulating lipoproteins, resides on the surface of the capillary endothelium. Analysis of a hypertriglyceridemic mutant mouse has now identified a protein, LMF1, that is critical for the transport of active lipoprotein lipase through the secretory pathway.

    • Alan D Attie
    News & Views
    Nature Genetics
    Volume: 39, P: 1424-1425

  • Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.

    • Alan D Attie
    • Christina M Kendziorski
    News & Views
    Nature Genetics
    Volume: 34, P: 244-245

  • Recent genome-wide association studies have identified many genes associated with metabolic disorders. However, systems-biology approaches could give improved insights into the complex involvement of genetic and environmental factors.

    • Aldons J. Lusis
    • Alan D. Attie
    • Karen Reue
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 819-830

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137