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Showing 1–5 of 5 results
Advanced filters: Author: Alan D Cherrington Clear advanced filters

  • New insights into the actions of the hormone glucagon are provided by a recent study in rodents, which shows that glucagon can suppress hepatic glucose production by acting through the mediobasal hypothalamic region of the brain. This central regulatory mechanism is impaired in rats fed a high-fat diet, suggesting that hypothalamic glucagon resistance may be relevant to the hyperglycemia observed in obesity, diabetes or both (pages 766–772).

    • Dale S Edgerton
    • Alan D Cherrington
    News & Views
    Nature Medicine
    Volume: 19, P: 674-675

  • Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.

    • Frantisek Hubálek
    • Hanne H. F. Refsgaard
    • Thomas Kjeldsen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschöp and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.

    • Maximilian Kleinert
    • Christoffer Clemmensen
    • Matthias H. Tschöp
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 140-162