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Showing 1–5 of 5 results
Advanced filters: Author: Alan Ianeselli Clear advanced filters

  • Detailed microfluidics experiments and numerical simulations are used to analyse the role played by dew in the origin of life, and demonstrate that it can drive the first stages of Darwinian evolution for DNA and RNA.

    • Alan Ianeselli
    • Miguel Atienza
    • Dieter Braun
    ResearchOpen Access
    Nature Physics
    Volume: 18, P: 579-585

  • Complex coacervate microdroplets have been proposed as primordial cells, but their ability to evolve by fusion, growth and fission has not yet been demonstrated. Now, it has been shown that gas bubbles inside heated rock pores can drive the growth, fusion, division and selection of coacervate microdroplets.

    • Alan Ianeselli
    • Damla Tetiker
    • T.-Y. Dora Tang
    ResearchOpen Access
    Nature Chemistry
    Volume: 14, P: 32-39

  • Physical non-equilibria can drive cycles of replication and selection chemistries that play a role in the prebiotic replication of DNA and RNA. This Perspective offers insights from astrophysics, geoscience and microfluidics on how various environments on early Earth could have hosted such reactions.

    • Alan Ianeselli
    • Annalena Salditt
    • Dieter Braun
    Reviews
    Nature Reviews Physics
    Volume: 5, P: 185-195

  • High concentrations of prebiotic molecules and dry–wet cycles are difficult to achieve in a submerged system. Now, it has been shown that temperature gradients across gas bubbles in submerged rock pores can provide these conditions. Molecules are continuously accumulated at the warm side of bubbles at the gas–water interface, which enables or enhances many prebiotically relevant processes.

    • Matthias Morasch
    • Jonathan Liu
    • Dieter Braun
    Research
    Nature Chemistry
    Volume: 11, P: 779-788

  • Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.

    • Giovanni Spagnolli
    • Tania Massignan
    • Emiliano Biasini
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16