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Showing 1–3 of 3 results
Advanced filters: Author: Alan M Mathiowetz Clear advanced filters

  • BETP, a positive allosteric modulator of GLP-1R, a class B GPCR and an important therapeutic target for type II diabetes, covalently modifies two cysteine residues at the receptor's cytoplasmic face, where one of these enhances agonist-induced signaling. [In the version of the Table of Contents initially published, the labels for the BETP conditions were swapped in graphical abstract of the Nolte et al. article. The error has been corrected in the HTML and PDF versions of the Table of Contents.]

    • Whitney M Nolte
    • Jean-Philippe Fortin
    • Philip A Carpino
    Research
    Nature Chemical Biology
    Volume: 10, P: 629-631

  • A single trimethylated species is obtained in an on-resin N-methylation reaction of a cyclic hexapeptide. This regioselectivity is driven by conformation and the presence of intramolecular hydrogen bonds, and is correlated with membrane permeability of the peptides.

    • Tina R White
    • Chad M Renzelman
    • R Scott Lokey
    Research
    Nature Chemical Biology
    Volume: 7, P: 810-817