Nature Search

ATP receptor-mediated synaptic currents in the central nervous system

Frances A. Edwards
Alasdair J. Gibb
David Colquhoun
Research10 Sept 1992
Nature

Volume: 359, P: 144-147
Dynamic models in behavioural and evolutionary ecology

Alasdair Houston
Colin Clark
Marc Mangel
Reviews03 Mar 1988
Nature

Volume: 332, P: 29-34
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1

The mechanisms by which signalling proteins dynamically modulate neurotransmitter release remain poorly understood. Here, Cianiet al. show Wnt signalling influences vesicle pool availability in an activity-dependent manner via direct interactions with Dishevelled-1 and the synaptic vesicle calcium sensor Synaptotagmin-1.

Lorenza Ciani
Aude Marzo
Patricia C. Salinas
ResearchOpen Access24 Sept 2015
Nature Communications

Volume: 6, P: 1-13
Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

Synapse degeneration is an early feature of neurodegenerative diseases. Here the authors show that Wnts are endogenous regulators of synaptic maintenance and suggest that dysfunction in Wnt signalling contributes to synaptic degeneration at early stages in neurodegenerative diseases.

Soledad Galli
Douglas M. Lopes
Patricia C. Salinas
ResearchOpen Access16 Oct 2014
Nature Communications

Volume: 5, P: 1-13
Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg²⁺ and mechanism of memantine, an NMDAR antagonist.

Laura Fedele
Joseph Newcombe
Trevor G. Smart
ResearchOpen Access06 Mar 2018
Nature Communications

Volume: 9, P: 1-15
Neuroenergetics and the kinetic design of excitatory synapses

David Attwell
Alasdair Gibb
Reviews01 Nov 2005
Nature Reviews Neuroscience

Volume: 6, P: 841-849
Differential Activity by Polymorphic Variants of a Remote Enhancer that Supports Galanin Expression in the Hypothalamus and Amygdala: Implications for Obesity, Depression and Alcoholism

Scott Davidson
Marissa Lear
Alasdair MacKenzie
Research29 Jun 2011
Neuropsychopharmacology

Volume: 36, P: 2211-2221
Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI

Yanan Zhu
Rajiv Ramasawmy
Simon Walker-Samuel
ResearchOpen Access10 Oct 2018
Scientific Reports

Volume: 8, P: 1-11

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