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Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Epigenetic profiles can be predictive of macrophage transcriptional responses to influenza A virus infection in individuals of European and African ancestry. Ancestry-linked epigenetic differences appear to be genetically controlled.

Katherine A. Aracena
Yen-Lung Lin
Luis B. Barreiro
Research29 Feb 2024
Nature Genetics

Volume: 56, P: 408-419
Author Correction: An atlas of genetic influences on osteoporosis in humans and mice

John A. Morris
John P. Kemp
J. Brent Richards
Amendments and Corrections15 Apr 2019
Nature Genetics

Volume: 51, P: 920
An atlas of genetic influences on osteoporosis in humans and mice

Genome-wide association analyses identify 301 new loci influencing bone mineral density and 13 loci influencing fracture risk. Integrative analyses of epigenomic data and mouse knockout phenotypes provide additional insights into osteoporosis pathophysiology.

John A. Morris
John P. Kemp
J. Brent Richards
Research31 Dec 2018
Nature Genetics

Volume: 51, P: 258-266
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Adipose tissue varies depending on localization. Vijay et al. perform single-cell RNA sequencing in multiple adipose tissue depots from obese individuals and identify distinct subpopulations of endothelial cells, immune cells and pre-adipocytes.

Jinchu Vijay
Marie-Frédérique Gauthier
Elin Grundberg
Research23 Dec 2019
Nature Metabolism

Volume: 2, P: 97-109
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR

Nada Jabado, Jacek Majewski, Annie Huang and colleagues show that embryonal tumors with multilayered rosettes are characterized by a recurrent fusion of TTYH1 with the C19MC microRNA cluster. They further show that this fusion results in massive overexpression of a brain-specific isoform of DNMT3B, suggesting that this pediatric brain tumor is driven by epigenetic reactivation of an early developmental neurogenesis program.

Claudia L Kleinman
Noha Gerges
Nada Jabado
Research08 Dec 2013
Nature Genetics

Volume: 46, P: 39-44

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Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice

An atlas of genetic influences on osteoporosis in humans and mice

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR

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