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PET and SPECT in cardiovascular molecular imaging

Continuing our series of Reviews on Molecular Imaging, Drs. Dobrucki and Sinusas discuss the applications of PET and single photon emission CT (SPECT) for the evaluation of cardiovascular disease, including myocardial metabolism, neurohumoral activity, atherosclerosis, ventricular remodeling, and angiogenesis.

Lawrence W. Dobrucki
Albert J. Sinusas
Reviews24 Nov 2009
Nature Reviews Cardiology

Volume: 7, P: 38-47
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

Generalized arterial calcification of infancy (GACI) is a terminal disease caused by the ENPP1 enzyme deficiency. Here, Albrigh et al. show that ENPP1 enzyme replacement therapy prevents the ectopic calcifications and mortality in mice with GACI, suggesting a novel treatment for vascular calcification in humans.

Ronald A. Albright
Paul Stabach
Demetrios T. Braddock
ResearchOpen Access01 Dec 2015
Nature Communications

Volume: 6, P: 1-11
Cellular recovery after prolonged warm ischaemia of the whole body

OrganEx—an extracorporeal pulsatile-perfusion system with cytoprotective perfusate for porcine whole-body settings—preserved tissue integrity, decreased cell death and restored selected molecular and cellular processes across multiple vital organs after 1 h of warm ischaemia in pigs.

David Andrijevic
Zvonimir Vrselja
Nenad Sestan
Research03 Aug 2022
Nature

Volume: 608, P: 405-412
Restoration of brain circulation and cellular functions hours post-mortem

A specialized technology can restore and preserve microcirculation and cellular functions hours post-mortem in an isolated pig brain.

Zvonimir Vrselja
Stefano G. Daniele
Nenad Sestan
Research17 Apr 2019
Nature

Volume: 568, P: 336-343
Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine

Matthew P. Brennan
Albert J. Sinusas
Martha J. Harding
Research01 Mar 2009
Lab Animal

Volume: 38, P: 87-93
Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging

Konrad Pieszko
Aakash D. Shanbhag
Piotr J. Slomka
ResearchOpen Access01 May 2023
npj Digital Medicine

Volume: 6, P: 1-11
An extremely high dietary iodide supply forestalls severe hypothyroidism in Na⁺/I⁻ symporter (NIS) knockout mice

Giuseppe Ferrandino
Rachel R. Kaspari
Nancy Carrasco
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure

Daniel Pfau
Stephanie L. Thorn
Daniela Tirziu
ResearchOpen Access08 Apr 2019
Scientific Reports

Volume: 9, P: 1-13

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