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Showing 1–7 of 7 results
Advanced filters: Author: Albert Konijnenberg Clear advanced filters

  • Interest in oligonucleotide nanostructures has recently surged in basic and applied research. Here, the authors use native mass spectrometry and ion mobility to elucidate a prototypical hexameric DNA barrel structure as well as intermediates and byproducts of the assembly reaction.

    • Jeroen F. van Dyck
    • Jonathan R. Burns
    • Frank Sobott
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of this multidrug-resistance conferring pump.

    • Eamonn Reading
    • Zainab Ahdash
    • Argyris Politis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The Pseudomonas putida toxin GraT and antitoxin GraA form a type II toxin-antoxin module. Here the authors present the crystal structures of the GraA dimer, GraTA and GraA-DNA complexes and show that GraT contains a functionally important N-terminal intrinsic disordered region that prevents the binding of the GraTA complex to the operator.

    • Ariel Talavera
    • Hedvig Tamman
    • Remy Loris
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The Parkinson’s disease‐associated LRRK2 protein is a multidomain Roco protein with GTPase activity. Here the authors use a multidisciplinary approach to characterize the GTPase mechanism of a homologous bacterial Roco protein and give mechanistic insights into disease-causing LRRK2 mutations.

    • Egon Deyaert
    • Lina Wauters
    • Wim Versées
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • EPR spectroscopy analyses elucidate how lipids affect the conformational dynamics of a multidrug secondary transporter, LmrP, and indicate a key role of the lipid headgroups in shaping the conformational-energy landscape of the transporter.

    • Chloé Martens
    • Richard A Stein
    • Hassane S Mchaourab
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 744-751

  • Characterization of an enterohaemorrhagic E. coli toxin–antitoxin system reveals that the toxin AtaT specifically acetylates Met-tRNAfMet at the methionyl amine, making it incompetent for translation initiation, which inhibits translation.

    • Dukas Jurėnas
    • Sneha Chatterjee
    • Laurence Van Melderen
    Research
    Nature Chemical Biology
    Volume: 13, P: 640-646