The tumour suppressor protein VHL, which is inactivated in hereditary and sporadic forms of renal cell carcinoma, is found at the mitotic spindle in mammalian cells. VHL inactivation leads to unstable astral microtubules and spindle misorientation as well as to reduced levels of Mad2, resulting in spindle checkpoint weakening and genomic instability.
- Claudio R. Thoma
- Alberto Toso
- Wilhelm Krek
