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Showing 1–2 of 2 results
Advanced filters: Author: Alec Trub Clear advanced filters

  • It is becoming clear that heterogeneity in cancer cell cycles corresponds to variability of response to therapies targeting cyclin dependent kinases (CDKs). Here, the authors investigate CDK2-dependancy and response to CDK2 inhibition across different cancers, identifying markers of sensitivity and combinatorial therapeutic strategies.

    • Vishnu Kumarasamy
    • Jianxin Wang
    • Erik S. Knudsen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Statin therapy is associated with numerous cellular effects. Here, the authors show that statin treatment increases post-translational modifications on fatty acid synthase in the active site, revealing communication between the cholesterol and lipid biosynthetic pathways.

    • Alec G. Trub
    • Gregory R. Wagner
    • Matthew D. Hirschey
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14