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COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy in macaques upper respiratory tract.

Pauline Maisonnasse
Yoann Aldon
Roger Le Grand
ResearchOpen Access20 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

First-in-human trial of a self-assembling, ferritin nanoparticle-based influenza vaccine shows evidence that this new platform can elicit neutralizing and cross-reactive antibodies and has potential for further vaccine development.

Katherine V. Houser
Grace L. Chen
Colin Tran
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 383-391
Broadly neutralizing antibodies target a haemagglutinin anchor epitope

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk domain.

Jenna J. Guthmiller
Julianna Han
Patrick C. Wilson
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 314-320
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

Raffael Nachbagauer
Jodi Feser
Florian Krammer
Research07 Dec 2020
Nature Medicine

Volume: 27, P: 106-114
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation

Catherine A. Cotter
Maxinne A. Ignacio
Bernard Moss
ResearchOpen Access24 Dec 2024
npj Vaccines

Volume: 9, P: 1-12