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Showing 1–9 of 9 results
Advanced filters: Author: Aled J. Parry Clear advanced filters

  • Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.

    • Ioana Olan
    • Aled J. Parry
    • Masashi Narita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.

    • Aled J. Parry
    • Wolf Reik
    News & Views
    Nature Genetics
    Volume: 54, P: 537-538

  • The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain boundaries and chromatin loops constitutive to all cell types.

    • Amanda Khoury
    • Joanna Achinger-Kawecka
    • Susan J. Clark
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The epigenetic priming factors DPPA2 and DPPA4 are required for efficient ESC differentiation because they maintain bivalency at developmental promoters and protect them from DNA methylation, thereby poising them for future lineage-specific activation.

    • Mélanie A. Eckersley-Maslin
    • Aled Parry
    • Wolf Reik
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 696-705

  • Hoare et al. find that NOTCH1 regulates the switch between two distinct senescence-associated secretomes—the TGF-β pathway and pro-inflammatory cytokines—and that its inhibition promotes clearance of oncogene-induced senescent liver cells.

    • Matthew Hoare
    • Yoko Ito
    • Masashi Narita
    Research
    Nature Cell Biology
    Volume: 18, P: 979-992

  • Shankar Balasubramanian and colleagues examine endogenous DNA G-quadruplex (G4) structures in the context of chromatin by using G4 antibody-based ChIP–seq. They find that G4 structures are enriched in nucleosome-depleted regions and the promoters and 5′ UTRs of highly transcribed genes, suggesting a relationship between chromatin state, transcriptional output and G4 status.

    • Robert Hänsel-Hertsch
    • Dario Beraldi
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 48, P: 1267-1272