There exists a void in understanding the communication between classical and nonclassical endocrine signaling. Although progesterone receptor membrane component 1 (PGRMC1) is able to bind to progesterone, the exact signaling mechanism remains unknown. The authors demonstrate that a classical and nonclassical endocrine signaling crosstalk between the estrogen receptor and PGRMC1 exists, and that this crosstalk may promote the growth of breast cancers.
- Diego A. Pedroza
- Ramadevi Subramani
- Rajkumar Lakshmanaswamy
