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Manual segmentation of opacities and consolidations on CT of long COVID patients from multiple annotators

Diedre S. Carmo
Alejandro A. Pezzulo
Alejandro P. Comellas
ResearchOpen Access07 Mar 2025
Scientific Data

Volume: 12, P: 1-7
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

A study reports the isolation and characterization of mouse-adapted SARS-CoV-2, demonstrates asapiprant to protect aged mice from its most severe effects, and identifies the PLA₂G2D–PGD₂/PTGDR pathway as a therapeutic target.

Lok-Yin Roy Wong
Jian Zheng
Stanley Perlman
Research21 Mar 2022
Nature

Volume: 605, P: 146-151
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.

Alejandro A. Pezzulo
Xiao Xiao Tang
Joseph Zabner
Research04 Jul 2012
Nature

Volume: 487, P: 109-113
Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Bradley A. Hamilton
Xiaopeng Li
Joseph Zabner
Research08 Apr 2019
Gene Therapy

Volume: 26, P: 240-249
Performance of a scalable RNA extraction-free transcriptome profiling method for adherent cultured human cells

Shreya Ghimire
Carley G. Stewart
Alejandro A. Pezzulo
ResearchOpen Access30 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model

In this study, the authors assess the early pathogenesis of cystic fibrosis (CF) pig gallbladder disease. The CF pig gallbladder epithelium lacks cAMP-stimulated anion and fluid transport. CF pig gallbladders also demonstrate increased luminal mucins MUC5AC and MUC5B accumulation without significant changes in the epithelial expression of gel-forming mucins compared to non-CF pigs.

Keyan Zarei
Mallory R. Stroik
David A. Stoltz
Research27 Jul 2020
Laboratory Investigation

Volume: 100, P: 1388-1399

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Manual segmentation of opacities and consolidations on CT of long COVID patients from multiple annotators

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Performance of a scalable RNA extraction-free transcriptome profiling method for adherent cultured human cells

Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model

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