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Showing 1–2 of 2 results
Advanced filters: Author: Alejandro Conde-Perez Clear advanced filters

  • The mechanism by which PTEN mutation is melanomagenic is complicated by different PTEN functions in different cellular locations. Here, the authors identify an alternative to membrane PI3K–AKT signalling, a caveolin-1-dependent PTEN pathway that induces nuclear localization and activation of β-catenin.

    • Alejandro Conde-Perez
    • Gwendoline Gros
    • Lionel Larue
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the regulation of melanocyte transport and skin pigmentation.

    • Zackie Aktary
    • Alejandro Conde-Perez
    • Lionel Larue
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15