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Showing 1–2 of 2 results
Advanced filters: Author: Alejandro Estaña Clear advanced filters
  • Using the site-specific incorporation of isotopically labeled glutamines and NMR, Elena-Real et al. identified helical stability of pathogenic huntingtin exon 1 as a key feature defining the aggregation propensity that triggers Huntington’s disease.

    • Carlos A. Elena-Real
    • Amin Sagar
    • Pau Bernadó
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 309-320
  • Foutel et. al. identify conformational buffering as a mechanism for functional selection in intrinsically disordered protein regions that allows robust encoding of a tethering function by a hypervariable disordered linker through compensatory changes in sequence length and composition.

    • Nicolás S. González-Foutel
    • Juliana Glavina
    • Lucía B. Chemes
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 781-790