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Showing 1–4 of 4 results
Advanced filters: Author: Alejandro Suárez-Bonnet Clear advanced filters

  • Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • Emilia L. Lim
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 159-167

  • Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.

    • Mylène Tajan
    • Marc Hennequart
    • Karen H. Vousden
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Enteric glial cells have tissue-wide immunoregulatory roles through the upregulation of IFNγ-dependent genes both at steady state and after parasite infection, promoting immune homeostasis and CXCL10-mediated tissue repair after pathogen-induced intestinal damage in mice.

    • Fränze Progatzky
    • Michael Shapiro
    • Vassilis Pachnis
    Research
    Nature
    Volume: 599, P: 125-130