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Advanced filters: Author: Alejandro Wolf-Yadlin Clear advanced filters

A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

Computational design enables the generation of a chimeric construct of the RAS exchange factor SOS that is specifically activated by a small molecule. The expression of this construct in different cell types reveals distinct phosphorylation kinetics.

John C Rose
Po-Ssu Huang
Dustin J Maly
Research21 Nov 2016
Nature Chemical Biology

Volume: 13, P: 119-126
Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules

Nathan D Camp
Kyung-Soon Lee
Chris Hague
ResearchOpen Access16 Jun 2015
Cell Discovery

Volume: 1, P: 1-12

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A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules

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