Nature Search

Author Correction: Microglial immune checkpoint mechanisms

Aleksandra Deczkowska
Ido Amit
Michal Schwartz
Amendments and Corrections25 Jun 2018
Nature Neuroscience

Volume: 21, P: 1137
Publisher Correction: XCR1⁺ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Aleksandra Deczkowska
Eyal David
Ido Amit
Amendments and Corrections12 Jan 2022
Nature Medicine

Volume: 28, P: 214
XCR1⁺ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Single-cell analyses reveal cDC1 as conserved immunological drivers of non-alcoholic steatohepatitis in mice and humans

Aleksandra Deczkowska
Eyal David
Ido Amit
Research20 May 2021
Nature Medicine

Volume: 27, P: 1043-1054
Immune control of brain physiology

The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leveraged during development and hijacked in ageing.

Mariángeles Kovacs
Amaia Dominguez-Belloso
Aleksandra Deczkowska
Reviews31 Jan 2025
Nature Reviews Immunology

Volume: 25, P: 515-527
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.

Aleksandra Deczkowska
Orit Matcovitch-Natan
Michal Schwartz
ResearchOpen Access28 Sept 2017
Nature Communications

Volume: 8, P: 1-13
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

In Alzheimer's disease, PD-1 immune checkpoint blockade reduces pathology and improves memory in mice with established disease.

Kuti Baruch
Aleksandra Deczkowska
Michal Schwartz
Research18 Jan 2016
Nature Medicine

Volume: 22, P: 135-137
Systems neuroimmunology: current bottlenecks, research priorities and future directions

Strategies to advance the field of neuroimmunology by embracing its complexity via inclusion of its multidisciplinary properties were discussed at a meeting in Cold Spring Harbor. Attendees proposed fostering of open communications and funding of collaborations across disciplines, and the recognition that our understanding of the neuroimmune system requires interdisciplinary science.

Harini Iyer
Christophe Benoist
Robyn S. Klein
Comments & Opinion12 Feb 2025
Nature Immunology

Volume: 26, P: 325-329
NASH limits anti-tumour surveillance in immunotherapy-treated HCC

In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

Dominik Pfister
Nicolás Gonzalo Núñez
Mathias Heikenwalder
ResearchOpen Access24 Mar 2021
Nature

Volume: 592, P: 450-456
The interaction of CD4⁺ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Amit and colleagues report that the specific interaction of a CD4⁺PD-1⁺CXCL13⁺ T-cell subset with antigen-presenting cells reprograms the tumor microenvironment and response to immune checkpoint inhibitors in non-small cell lung cancer.

Merav Cohen
Amir Giladi
Ido Amit
Research03 Mar 2022
Nature Cancer

Volume: 3, P: 303-317
Breaking immune tolerance by targeting Foxp3⁺ regulatory T cells mitigates Alzheimer’s disease pathology

Immunosuppression has been unsuccessful in treatment of Alzheimer’s disease. Here the authors show in a mouse model of the disease that transient inhibition of regulatory T cells mitigates amyloid plaque pathology and reverses cognitive decline, whereas augmenting these cells worsens the pathology.

Kuti Baruch
Neta Rosenzweig
Michal Schwartz
ResearchOpen Access18 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Microglial immune checkpoint mechanisms

Microglial immune checkpoint mechanisms are signaling pathways that limit immune responsiveness and promote homeostatic activities of micrroglia throughout life, but can interfere with repair mechanisms in disease.

Aleksandra Deczkowska
Ido Amit
Michal Schwartz
Reviews07 May 2018
Nature Neuroscience

Volume: 21, P: 779-786

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