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Showing 1–2 of 2 results
Advanced filters: Author: Aleksandra Turp Clear advanced filters

  • Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) have distinct developmental origins. Genome-wide expression and global DNA-methylation analyses now reveal that ESCs and ESGs are highly similar at the transcriptome level and, contrary to previous assumptions, are both characterized by DNA hypomethylation. Also, global methylation levels in both ESCs and EGCs are directly responsive to culture conditions.

    • Harry G Leitch
    • Kirsten R McEwen
    • Petra Hajkova
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 311-316

  • Using ultrasensitive mass spectrometry of wild-type and mutant early mouse zygotes, Hajkova and colleagues show that 5mC loss and 5hmC accumulation are uncoupled during zygotic epigenetic reprogramming.

    • Rachel Amouroux
    • Buhe Nashun
    • Petra Hajkova
    Research
    Nature Cell Biology
    Volume: 18, P: 225-233