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Showing 1–5 of 5 results
Advanced filters: Author: Aleksei Mikhalchenko Clear advanced filters

  • Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

    • Nuria Marti Gutierrez
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

    • Dan Liang
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The mitochondrial transcription factor A is excluded from the mitochondria in spermatozoa by virtue of phosphorylation of the mitochondrial presequence. This is associated with transport to the nucleus and loss of mitochondrial DNA (mtDNA) from the mitochondria, providing a mechanistic basis for uniparental inheritance of mtDNA in humans.

    • William Lee
    • Angelica Zamudio-Ochoa
    • Dmitry Temiakov
    Research
    Nature Genetics
    Volume: 55, P: 1632-1639

  • Yeonmi Lee, Aysha Trout, Nuria Marti-Guiterrez et al. examine different aspects of somatic cell haploidization in mouse enucleated oocytes. Their results provide further insight into generating oocytes carrying somatic genomes.

    • Yeonmi Lee
    • Aysha Trout
    • Eunju Kang
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15