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Showing 1–10 of 10 results
Advanced filters: Author: Alessandra Breschi Clear advanced filters

  • Breschi et al. investigated proteomic profiles from the Project Baseline Health Study cohort to identify whether there are differential plasma profiles associated with type 2 diabetes. They find that integration of proteomic and clinical data could enable a more refined risk-based stratification of individuals with normoglycemia or prediabetes.

    • Alessandra Breschi
    • Yuliang Wang
    • Charles C. Kim
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-14

  • The analysis of mammalian transcriptomes could provide new insights into human biology. Here the authors carry out RNA sequencing in a large collection of mouse tissues and compare these data to human transcriptome profiles, identifying a set of constrained genes that carry out basic cellular functions with remarkably constant expression levels across tissues and species.

    • Dmitri D. Pervouchine
    • Sarah Djebali
    • Thomas R. Gingeras
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • The Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types; these data were compared with those from human to confirm substantial conservation in the newly annotated potential functional sequences and to reveal pronounced divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.

    • Feng Yue
    • Yong Cheng
    • Bing Ren
    ResearchOpen Access
    Nature
    Volume: 515, P: 355-364

  • RNA levels in post-mortem tissue can differ greatly from those before death. Studying the effect of post-mortem interval on the transcriptome in 36 human tissues, Ferreira et al. find that the response to death is largely tissue-specific and develop a model to predict time since death based on RNA data.

    • Pedro G. Ferreira
    • Manuel Muñoz-Aguirre
    • Roderic Guigó
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • Next-generation sequencing technologies have enabled the comprehensive characterization of human and mouse genomes, including at the transcriptional level. This article reviews the degree of conservation of human and mouse transcriptomes, along with the challenges of identifying when the mouse is a suitable model of human physiology.

    • Alessandra Breschi
    • Thomas R. Gingeras
    • Roderic Guigó
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 425-440

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698