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Discovery and engineering of the antibody response to a prominent skin commensal

Staphylococcus epidermidis induces a potent, durable and specific antibody response that is conserved in humans and non-human primates, and which could be redirected against pathogens as a new form of topical vaccination.

Djenet Bousbaine
Katherine D. Bauman
Michael A. Fischbach
Research11 Dec 2024
Nature

Volume: 638, P: 1054-1064
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

Biomarker analysis of the phase 4 R4RA trial identifies pretreatment synovial biopsy features selectively associated with response to rituximab or tocilizumab, and leads to the development of models that might predict treatment benefit in patients with rheumatoid arthritis

Felice Rivellese
Anna E. A. Surace
Costantino Pitzalis
ResearchOpen Access19 May 2022
Nature Medicine

Volume: 28, P: 1256-1268
Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

Linda Sawade
Federica Grandi
Volker Haucke
ResearchOpen Access05 Jun 2020
Nature Communications

Volume: 11, P: 1-18
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Here, the authors propose that SARS-CoV-2 induces a prothrombotic state, with dysregulated immunothrombosis in lung microvessels and endothelial injury, which drive the clinical manifestations of severe COVID-19. They discuss potential antithrombotic and immunomodulating drugs that are being considered in the treatment of patients with COVID-19.

Aldo Bonaventura
Alessandra Vecchié
Antonio Abbate
Reviews06 Apr 2021
Nature Reviews Immunology

Volume: 21, P: 319-329
A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA

Daniela Pignataro
Sofia Francia
Alessandra Montecucco
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage

Martina Magni
Giacomo Buscemi
Laura Zannini
Research26 Jul 2018
Cell Death & Differentiation

Volume: 26, P: 918-931

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Discovery and engineering of the antibody response to a prominent skin commensal

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA

TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage

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