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Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease

Early expression of intraneuronal amyloid-β (not phospho-tau) and inflammatory and glycosylation pathway transcripts distinguish neocortical RORB⁺ and GAD1⁺ neurons selectively vulnerable to neurodegeneration in Alzheimer’s disease.

Alessia Caramello
Nurun Fancy
Paul M. Matthews
ResearchOpen Access04 Jun 2025
Nature Communications

Volume: 16, P: 1-19

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Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease

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